Advantus (imidacloprid) soft chew flea treatment for Large Dogs, 23-110 lbs, 7 doses Advantus (Imidacloprid) 7-Count Large Dog Flea Chewable Treatment, for Dogs 23-110 Pounds "Advantus large dog flea chewables are a fast-acting treatment of flea infestations. Advantus 7-count chewable flea treatment for dogs starts killing fleas within 1 hour with just a single dose. In the event of continued infestation, you can repeat treatment as often as once per day. These flavored soft chews are for dogs and puppies 10 weeks of age and older. You can treat immediately when you see fleas on your dog. Advantus soft chews were designed with flexibility in mind, so you can use one chew per day because the active ingredient quickly dissipates in your dog's system. If your dog has food allergies to ingredients like chicken or beef, Advantus is a suitable option because it does not contain any animal protein.